Solid target processing system for ²²⁵Ac production

Due to its clinical significance, Targeted Alpha Therapy (TAT) has attracted a special attention.

Actinium-225 (²²⁵Ac, α = 100%, T1/2 = 9.92 days) is a promising radionuclide usable for TAT. However, its production on a wide scale is in the development stage, while the global demand has increased. Compared to the worldwide demand of ²²⁵Ac, the amount produced via depleted thorium-229 sources is minimal, making it an expensive radionuclide. Alternative production routes (including cyclotrons, reactors and high-energy linear accelerators) are therefore widely desired.

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